The Effect of Cinnamon Volatile Oil on Candida albicans strain H303

Anek Pootong, Onruedee Khantisitthiporn, Benja Norrapong, Suwanna Cowawintaweewat

Abstract


The aim of this study was to evaluate the antifungal effects of cinnamon volatile oil on pathogenic C. albicans. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of cinnamon volatile oil against C. albicans H 303 were 125 µg/mL. At sub-inhibitory concentration, cinnamon volatile oil reduced germ tube formation and phospholipase activity of C. albicans H 303 in dose dependent manner. By using gas chromatography-mass spectrometry (GC-MS) analysis, cinnamaldehyde was found as the main component (87%). This study showed that cinnamon volatile oil has a potent in vitro activity against C. albicans and can inhibit the activities of virulence factors.


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